环境化学物暴露与急性淋巴细胞白血病关系的研究进展
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王利,本科,护师,主要研究方向:血液病相关性疾病

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R181

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Research progress on relationship between environmental chemical exposure and acute lymphoblastic leukemia
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    摘要:

    急性淋巴细胞白血病(acute lymphoblastic leukemia , ALL)是一种常见的血液系统恶性肿瘤,其恶性程度高,危害大,且复发率较高,加之治疗过程复杂,治疗费用高,不仅给患者带来极大的痛苦,还增加了患者家庭,乃至社会的经济负担。关于ALL发病机制目前尚无定论,但据研究发现,环境因素与遗传因素在ALL发病中可能发挥着重要作用。故本文总结近年有关环境化学暴露因素与ALL表观遗传研究的报道,试综述环境化学物暴露与ALL发病机制的关系,为临床研究提供参考思路。

    Abstract:

    Acute lymphoblastic leukemia (ALL) is a common hematological malignant tumor with high malignancy , great harm and high recurrence rate. In addition, the treatment process of ALL is complicated and the treatment cost is high , which not only brings great pain to patients , but also increases the economic burden of patients’ families and even society . The pathogenesis of ALL is still inconclusive , but studies have found that environmental factor and genetic factor may play an important role in the pathogenesis of ALL . Therefore , this paper summarizes the reports on environmental chemical exposure factors and ALL epigenetics studies in recent years , and tries to review the relationship between environmental chemical exposure and pathogenesis of ALL , so as to provide reference ideas for clinical research .

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  • 收稿日期:2024-12-13
  • 最后修改日期:2024-12-13
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  • 在线发布日期: 2025-01-15
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