西安市非小细胞肺癌患者驱动基因突变与环境暴露因素的相关性分析
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胡阳,本科,主管护师,主要研究方向:肺癌疾病的防治

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R181

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Correlation between driver gene mutation and environmental exposure factors in patients with non-small cell lung cancer in Xi’ an City
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    摘要:

    目的 了解西安市非小细胞肺癌(non-smal cel lung cancer,NSCLC)患者驱动基因突变情况,分析其与环境暴露因素的关联性。方法 纳入2019年1月~2023年12月空军军医大学第一附属医院收治的305例NSCLC患者,观察其驱动基因突变情况,分析其与环境暴露因素的关系。结果 305例患者驱动基因突变率为46.89%,以EGFR基因突变占比最高,同时检出4例基因共突变;不同单驱动基因突变患者在性别上存在差异(P<0.05),EGFR以女性占比明显较高(P<0.05);单因素分析显示:驱动基因突变与非驱动基因突变患者在家族史、吸烟史、长期烹饪史、煎炸烟熏食物摄取间比较差异有统计学意义(P<0.05);logistic回归分析显示:长期烹饪史(OR=2.392)、煎炸烟熏食物摄取(OR=2.849)是影响EGFR基因突变环境暴露因素(P<0.05),有吸烟史(OR=1.377)是KRAS基因突变环境暴露因素(P<0.05)。结论 西安市NSCLC患者以EGFR基因突变占比最高,且以女性为主,长期烹饪史、煎炸烟熏食物摄取与EGFR基因突变有关,有吸烟史与KRAS基因突变有一定的关联性。

    Abstract:

    Objective To understand the driver gene mutation status in patients with non-small cell lung cancer (NSCLC) in Xi’ an City, and to analyze the association with environmental exposure factors. Methods A total of 305 NSCLC patients admitted to the First Affiliated Hospital of the Air Force Medical University from January 2019 to December 2023 were included. The driver gene mutation status was observed, and the relationship with environmental exposure factors was analyzed. Results The driver gene mutation rate of 305 patients was 46.89%, with EGFR gene mutation accounting for the highest proportion, and 4 cases of gene co-mutations were detected. There was a difference in gender among patients with different single drive gene mutations (P<0.05), and the proportion of EGFR in women was significantly higher (P<0.05). Univariate analysis showed that there were statistical differences in family history, smoking history, long-term cooking history, and fried smoked food intake between patients with driver gene mutation and patients without driver gene mutation (P<0.05). Logistic regression analysis suggested that long-term cooking history (OR=2.392), and fried smoked food intake (OR=2.849) were the environmental exposure factors affecting EGFR gene mutation (P<0.05), and smoking history (OR=1.377) was an environmental exposure factor of KRAS gene mutation (P<0.05). Conclusion EGFR gene mutation accounts for the highest proportion of NSCLC patients in Xi’ an City, and is mainly female. Long-term cooking history, and fried smoked food intake are related to EGFR gene mutation. There is a certain association between smoking history and KRAS gene mutation.

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  • 收稿日期:2024-12-05
  • 最后修改日期:2024-12-05
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  • 在线发布日期: 2025-01-15
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