2015—2020年晋城市非酒精性脂肪性肝病流行病学特征及风险因素分析
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张妮娜,本科,副主任医师。主要研究方向:消化内科肝病方向

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R181

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Epidemiological Characteristics and Risk Factors of Non-alcoholic Fatty Liver Disease in Jincheng between 2015 and 2020
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    摘要:

    目的 探究2015—2020年晋城市人民医院体检人群非酒精性脂肪性肝病流行病学特征及风险因素分析。 方法 回顾性的选取2015年1月-2020年12月于体检中心接受体检8 578名人员的临床资料,分析近5年非酒精性脂肪性肝病流行情况,应用logistic回归分析非酒精性脂肪性肝病发病的风险因素。 结果 2015—2020年晋城市非酒精性脂肪性肝病患病率为14.57%,男性患病率(16.99%)高于女性(10.98%),40-59岁年龄段患病率(18.76%)最高。两组患者血清BUN、Scr水平差异无统计学意义(P>0.05),糖尿病、高血压、BMI、腰围、每周运动情况、每日蔬菜摄入量、TG、TC、LDL-C、HDL-C、ALT、UA水平差异有统计学意义(P<0.05)。多因素logistic回归结果显示,BMI(OR=2.794,95%CI:1.745-4.550)、腰围(OR=2.586,95%CI:1.585-4.299)、糖尿病(OR=1.508,95%CI:1.425-2.781)、高血压(OR=1.479,95%CI:1.121-2.290)、每周运动≥6h(OR=0.644,95%CI:0.519-0.709)、每日蔬菜摄入≥300g(OR=0.590,95%CI:0.467-0.652)、TG(OR=1.481,95%CI:1.122-1.996)、TC(OR=1.562,95%CI:1.143-2.135)、LDL-C(OR=1.440,95%CI:1.139-2.048)、HDL-C(OR=0.656,95%CI:0.587-0.783)、ALT(OR=1.591,95%CI:1.056-2.183)、UA(OR=1.412,95%CI:1.009-1.887)都是非酒精性脂肪性肝病的风险因素(P<0.05)。都是非酒精性脂肪性肝病的风险因素(P<0.05)。 结论 2015—2020年晋城市非酒精性脂肪性肝病患病率为14.57%,男性患病率高于女性,40-59岁年龄段患病率最高,糖尿病、高血压、BMI、腰围、每周运动情况、每日蔬菜摄入量、血清TG、TC、LDL-C、HDL-C、ALT、UA水平均与该疾病的风险存在关联。

    Abstract:

    Objective To investigate the epidemiological characteristics and risk factors of non-alcoholic fatty liver disease in Jincheng between 2015 and 2020. Methods Clinical data of 8,578 medical check-ups at Physical Examination Center of ou hospital from January 2015 to December 2020 were retrospectively selected. The prevalence of non-alcoholic fatty liver disease in the last 5 years was recorded, and Logistic regression was utilized to identify the risk factors for the development of non-alcoholic fatty liver disease. Results The overall prevalence of non-alcoholic fatty liver disease in Jincheng was 14.57% in 2015-2020. The prevalence of non-alcoholic fatty liver disease was higher in men than in women (16.99% vs 10.98%) and highest in the 40-59 age group (18.76%). No statistical difference was reported in blood urea nitrogen (BUN) and serum creatinine (Scr) between groups (P>0.05), while statistical difference was found in diabetes, hypertension, body mass index (BMI), waist circumference, weekly exercise frequency, daily vegetable intake, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT) and uric acid (UA) between two groups (P<0.05). Multivariate Logistic regression analysis denoted that BMI (OR=2.794, 95% CI: 1.745-4.550), waist circumference (OR=2.586, 95% CI: 1.585-4.299), diabetes (OR=0.644, 95% CI: 1.425-2.781), hypertension (OR=1.479, 95% CI: 1.121-2.290), weekly exercise ≥6h (OR=0.617, 95% CI: 0.519-0.709), daily vegetable intake ≥300g (OR=0.590, 95% CI: 0.467-0.652), TG (OR=1.481, 95% CI: 1.122-1.996), TC (OR=1.562, 95% CI:1.143-2.135), LDL-C (OR=1.440, 95% CI: 1.139-2.048), HDL-C (OR=0.656 , 95% CI: 0.587-0.783) , ALT (OR=1.591, 95% CI: 1.056-2.183), and UA (OR=1.412, 95% CI: 1.009-1.887) were risk factors for non-alcoholic fatty liver disease (P<0.05) . Conclusion The prevalence of non-alcoholic fatty liver disease in Jincheng City from 2015 to 2020 is 14.57%, the prevalence of males is higher than that of females, and the prevalence rate is the highest in the 40-59 age group. Moreover , diabetes mellitus , hypertension , BMI , waist circumference , weekly exercise , daily vegetable intake , serum TG, TC, LDL-C, HDL-C, ALT, and UA are all associated with the risk of the disease .

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  • 收稿日期:2024-12-19
  • 最后修改日期:2024-12-19
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  • 在线发布日期: 2025-01-15
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