肥胖2型糖尿病患者IL-6、chemerin、脂质比值与胰岛素抵抗的相关性分析
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罗伊丽,硕士,主治医师,主要研究方向:慢性、代谢性疾病的防治

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R183

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Correlation between IL-6 , chemerin , lipid ratio and insulin resistance in obese patients with type 2 diabetes mellitus
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    摘要:

    目的 了解肥胖2型糖尿病(type 2 diabetes mellitus , T2DM)患者白介素-6(IL-6)、趋化素(chemerin)、总胆固醇(TC)与高密度脂蛋白胆固醇(HDL-C)比值、甘油三酯(TG)与HDL-C比值、低密度脂蛋白胆固醇(LDL-C)与HDL-C比值与胰岛素抵抗的相关性,为T2DM防控提供科学依据。方法 选取2021年1月至2023年12月上海交通大学医学院附属松江医院收治的355例肥胖T2DM患者,均进行IL-6、chemerin和脂质检测,并通过稳态模型评估胰岛素抵抗指数(HOMA-IR)。结果 355例肥胖T2DM患者中,发生胰岛素抵抗者280例,即胰岛素抵抗发生率为78.87%。胰岛素抵抗组BMI、IL-6、chemerin、TC/HDL-C、LDL-C/HDL-C、TG/HDL-C均大于无胰岛素抵抗组(P<0.05)。根据胰岛素抵抗分为4个亚组,各亚组BMI、IL-6、chemerin、TG/HDL-C比较差异均显著(P<0.05)。肥胖T2DM患者IL-6、chemerin、TG/HDL-C与HOMA-IR呈成正相关(P<0.05),TC/HDL-C、LDL-C/HDL-C与HOMA-IR无明显相关性(P>0.05)。BMI、IL-6、chemerin、TG/HDL-C均是肥胖T2DM患者胰岛素抵抗的影响因素(P<0.05)。结论 肥胖T2DM患者IL-6、chemerin、TG/HDL-C与胰岛素抵抗存在相关性,可能是胰岛素抵抗发生的影响因素。

    Abstract:

    Objective To investigate the correlation between insulin resistance and interleukin-6 (IL-6), chemerin, total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low density lipoprotein cholesterol (LDL-C)/HDL-C ratio and insulin resistance in obese patients with type 2 diabetes mellitus (T2DM), and to provide scientific basis for T2DM prevention and control. Methods A total of 355 obese T2DM patients in Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected from January 2021 to December 2023. IL-6, chemerin and lipids were detected, and the assessment of insulin resistance was conducted through the homeostasis model assessment of insulin resistance (HOMA-IR). Results Among the 355 obese T2DM patients, there were 280 cases of insulin resistance, with the incidence rate of 78.87%. The BMI, IL-6, chemerin, TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C in the insulin resistance group were higher than those in the non-insulin resistance group (P<0.05). The above insulin resistant patients were divided into 4 subgroups by means of insulin resistance, and there were significant differences in BMI, IL-6, chemerin, and TG/HDL-C among the subgroups (P<0.05). IL-6, chemerin, and TG/HDL-C were positively correlated with HOMA-IR in obese T2DM patients (P<0.05), while TC/HDL-C and LDL-C/HDL-C had no significant correlation with HOMA-IR (P>0.05). BMI, IL-6, chemerin, and TG/HDL-C were all influencing factors of insulin resistance in obese T2DM patients (P<0.05). Conclusion IL-6, chemerin and TG/HDL-C are correlated with insulin resistance in obese patients with T2DM and are influencing factors for the occurrence of insulin resistance.

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  • 收稿日期:2024-12-03
  • 最后修改日期:2024-12-03
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  • 在线发布日期: 2025-01-15
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