下丘脑延伸突触结合蛋白和能量平衡调控的关系研究
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关蕴良,博士,讲师,主要研究方向:能量代谢调控

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R181

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Study on the relationship between hypothalamus extended synaptotagmins and energy balance regulation
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    摘要:

    肥胖是机体能量调控失衡的重要表现,它的并发症会给机体带来不可修复的损害。从分子水平寻找肥胖的致病机理,才能从根本上避免这些不可逆转并发症的发生。延伸突触结合蛋白(extended synaptotagmins, E-Syts)是与内质网(endoplasmic reticulum, ER)和细胞膜(plasma membrane, PM)连接形成有关的蛋白。因发现时间不久,存在极大的探索空间。但就已确定的结构在分子水平发挥的作用来看,与肥胖的发病机制存在不可忽视的联系。本文从下丘脑其结构入手,搜寻这种联系的文献证据,期待为预防肥胖的发生及降低其患病率找到新的研究角度。

    Abstract:

    Obesity is an important manifestation of the imbalance of energy regulation, and its complications can cause irreparable damage to the body. Finding the pathogenesis of obesity at the molecular level can help fundamentally avoid these irreversible complications. Extended synaptotagmins (E-Syts) are proteins related to the formation of endoplasmic reticulum (ER) and plasma membrane (PM). Because of the short discovery time, there is huge room for exploration. In terms of the role of the established structure of E- Syts at the molecular level, it has a non-negligible link with the pathogenesis of obesity. Starting with the structure of hypothalamus, this paper reviews the literature evidence of this connection, hoping to find a new research angle for reducing the incidence of obesity.

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  • 收稿日期:2024-12-03
  • 最后修改日期:2024-12-03
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  • 在线发布日期: 2025-01-15
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