岳阳市出生缺陷综合防控信息平台的构建和应用
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彭赞平,硕士,检验师,主要研究方向:分子遗传

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R174

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Construction and application of the Yueyang comprehensive birth defects prevention and control information platform
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    摘要:

    目的:在岳阳市构建并应用基于三级防控的出生缺陷综合防控信息平台,旨在提升干预效果、降低胎儿的出生缺陷发生率。方法:采用回顾性分析,研究对象为我院2017年1月~2019年12月户籍在岳阳市的已婚育龄生育人口及新生儿,均纳入基于三级防控的出生缺陷综合防控信息平台进行干预。观察指标包括出生缺陷一、二、三级防控及干预效果。结果:(1)各年度一级防控的效果:经过持续干预,岳阳市的宣教率、婚检率、叶酸发放数逐年提升,而出生缺陷的发生率逐年下降(P<0.05)。(2)各年度二级防控的效果:经过持续干预,岳阳市的血清筛查率、超声诊断率、羊水培养率逐年提升,而出生缺陷的出生率逐年下降(P<0.05)。(3)各年度三级防控的效果:经过持续干预,岳阳市的新生儿筛查率逐年提升(P<0.05);而三年内CH、PKU、48种遗传代谢病和G6PD致残率均为0%。结论:在出生缺陷的防控中采用三级综合防控信息平台具有安全、高效、稳定的应用优势,有利于促进孕妇积极行产前检查,提升健康教育的宣教效果,改善妊娠阶段的保健质量,进而有效降低出生缺陷患儿的发生、出生及致残率,取得满意的分级应用效果。因此,建议依据实际情况优先选择三级综合信息平台进行防控。

    Abstract:

    Objective To construct and apply a comprehensive information platform for the prevention and control of birth defects based on three-level prevention and control in the birth-age population of Yueyang City, aiming to improve the effectiveness of intervention and reduce the impact of birth defects on the fetus. Methods A retrospective analysis was used to study the married population of childbearing age in Yueyang from January 2017 to December 2019, all of whom were included in the comprehensive information platform for the prevention and control of birth defects based on the three-tier prevention and control. Observed indicators include birth defects I, II and III prevention and control and intervention effectiveness. Results (1) Effectiveness of prevention and control at the first level in each year: After continuous intervention, the education rate, marriage test rate and folic acid distribution in Yueyang city increased year by year, while the incidence of birth defects decreased year by year (P<0.05). (2) Effect of secondary prevention and control in each year: After continuous intervention, the serum screening rate, ultrasound diagnosis rate and amniotic fluid culture rate in Yueyang city increased year by year, while the birth defect rate decreased year by year (P<0.05). (3) Effectiveness of three levels of prevention and control in each year: After continuous intervention, the screening rate of newborns in Yueyang city increased year by year (P<0.05); and the disability rate of CH and PKU was 0% in three years. Conclusions The adoption of a three-level comprehensive prevention and control information platform in the prevention and control of birth defects has the advantages of safe, efficient and stable application, which is conducive to promoting the active conduct of prenatal examinations by pregnant women, enhancing the effectiveness of health education and improving the quality of health care during pregnancy, thereby effectively reducing the incidence, birth and disability rates of children with birth defects and achieving satisfactory graded application results. Accordingly, it is recommended that priority be given to the selection of a three-tier integrated information platform for prevention and control, depending on the actual situation..

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  • 收稿日期:2022-03-10
  • 最后修改日期:2022-03-10
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  • 在线发布日期: 2022-07-22
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