2017—2021年西安市HIV感染者不同基因型CD4+T细胞计数分析
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张婧 ,主治医师 主要研究方向:预防保健,传染病管理,慢病管理

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R183

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Analysis of CD4 + T cell count of different genotypes of HIV infected people in Xi'an in 2017 -2021
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    摘要:

    目的 研究2017—2021年西安市HIV感染者不同基因型CD4+T细胞计数之间的差异。方法 选取西安市2017—2021年艾滋病综合防治信息系统中新报告的艾滋病患者1 623例作为研究对象,分别对所有患者的基因型进行测序,分析不同基因型患者的CD4+T细胞计数之间的差异。结果 2017—2021年西安市HIV感染者的基因亚型主要为CRF01_AE(921/1623)、CRF07_BC(145/1623)、CRF08_BC(557/1623),基因亚簇主要为CRF01_AE (Cluster 1)(185/1623)以及CRF01_AE (Cluster 2)(1438/1623),其中CRF01_AE基因型CD4+T细胞计数平均为(146.26±11.63)个/μL,CRF07_BC基因型CD4+T细胞计数平均为(254.69±15.49)个/μL,CRF08_BC基因型CD4+T细胞计数平均为(217.96±12.89)个/μL,CRF01_AE (Cluster 1) CD4+T细胞计数平均为(185.58±12.79)个/μL,CRF01_AE (Cluster 2) CD4+T细胞计数平均为(179.90±15.96)个/μL,不同基因亚型以及基因亚簇患者的CD4+T细胞计数之间的差异存在统计学意义(P<0.05)。结论 2017—2021年西安市HIV感染者的基因亚型主要为CRF01_AE,基因亚簇主要为CRF01_AE (Cluster 2),不同基因亚型以及基因亚簇患者的CD4+T细胞计数存在显著差异,可作为本市艾滋病患者治疗的参考靶点之一。

    Abstract:

    Objective To study the difference of CD4 + T cell count among different genotypes of HIV infected people in Xi'an from 2017 to 2021. Methods A total of 1 623 newly diagnosed AIDS patients in the AIDS prevention and control information system in Xi'an from 2017 to 2021 were selected. The genotypes of all the patients were sequenced, and the differences of CD4+T cell counts among different genotypes were analyzed. Results From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE(921/1623)、CRF07_ BC(145/1623)、CRF08_ BC (557 / 1623), the gene cluster is mainly CRF01_ AE (cluster 1) (185 / 1623) and CRF01_ AE (cluster 2) (1438 / 1623), where CRF01_ The average CD4 + T cell count of AE genotype was (146.26 ± 11.63)/ μ L,CRF07_ The average CD4 + T cell count of BC genotype was (254.69 ± 15.49)/ μ L,CRF08_ The average CD4 + T cell count of BC genotype was (217.96 ± 12.89)/ μ L,CRF01_ The average number of CD4 + T cells in AE (cluster 1) was (185.58 ± 12.79)/ μ L,CRF01_ The average number of CD4 + T cells in AE (cluster 2) was (179.90 ± 15.96)/ μ 50. There was significant difference in CD4 + T cell count among patients with different gene subtypes and gene clusters (P < 0.05). Conclusion From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE, the gene cluster is mainly CRF01_ AE (Cluster 2), there were significant differences in CD4+T cell counts among patients with different gene subtypes and gene subsets, which could serve as a reference target for AIDS treatment in this Municipality.

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  • 收稿日期:2022-05-10
  • 最后修改日期:2022-05-10
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  • 在线发布日期: 2022-07-21
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