Abstract:Objective To analyse and study the epidemic and clinical characteristics of Hemorrhagic fever with renal syndrome in Southern Anhui Province during 2010-2020. Methods To gateher the epidemic and clinical data of HFRS patients that hospitalized in Yijishan hospital of Wannan medical college during 2010-2020 and analyze the epidemic and clinical characteristics of these patients. Results The temporal distribution of HFRS in Southern Anhui Province showed that HFRS were more frequent during spring and summer, and HFRS morbidity was highest in June. The results of population distribution showed that the morbidity of males were 4.69 times as females, the,morbidity of male was 2.61/100000 and 0.58/100000 for female, there were statistic significance between the morbidity of male and female(χ2 = 57.932,P < 0.001) ,individuals during 40-50 (50 cases, 33.80%) were more vulnerable to HFRS,the morbidity of male and female in different age group were not statisticly significant, farmers (87 cases, 58.78%) were most susceptible to HFRS. Clinical analyses showed that fever, backache, anorexia and hypodynamia, diarrhea, emesis and headache were the main frequent symptoms of HFRS patients in Southern Anhui Province, 88.52% of HFRS patients were cured or improved. Conclusion The morbidity of HFRS are higher in spring and summer in Southern Anhui Provinceduring 2010-2020. Male were significantly vulnerable to HFRS than female.The clinical features of HFRS in Southern Anhui Province are that HFRS patients have typical clinical symptoms and good progonosis.