2016—2020年达州市不同人群乙肝五项标志物结果分析

Analysis of five markers of hepatitis B in different population in Dazhou citys from 2016 to 2020

摘要:

目的 分析2016～2020年达州市不同人群乙肝五项标志物检测情况。方法 收集2016年1月～2020年12月在达州市三所综合医院进行乙肝五项标志物检查者36782例的检测资料并进行统计分析。结果2016～2020年达州市乙肝病毒（Hepatitis B virus，HBV）表面抗原（Hepatitis B surface antigen，HBsAg）阳性率为2.43%，HbsAg阳性率年度变化呈现下降趋势（χ2=57.274，P＜0.001）；男性HbsAg阳性率（2.82%）高于女性（2.04%）（χ2=42.482，P＜0.001）；不同年龄段HbsAg阳性率差异有统计学意义（χ2=246.595，P＜0.001），其中≤5岁阳性率最低（0.76%），35～54岁年龄段阳性率最高（3.07%）；HbsAg携带主要模式大三阳（22.60%）、小三阳（41.95%）和1,5阳（23.60%），共占88.15%；男性1,5阳阳性率（25.58%）高于女性（20.90%）（χ2=18.645，P＜0.05）；35～54岁年龄段人群1,5阳阳性率（30.77%）与小三阳阳性率（62.33%）最高；15～24岁年龄段人群大三阳阳性率（41.46%）最高；五项全阴性率60.11%，其中≤5年龄段阴性率最高（77.67%）。结论 近五年达州市男性HbsAg阳性率高于女性，且以青壮年群体为主，今后应将其作为重点防治的对象，并同时关注儿童群体，主要侧重大三阳、小三阳以及全阴模式人群的防治，做好三级预防工作。

Abstract:

Objective. To analyze the detection of five markers of hepatitis B in different population in Dazhou from 2016 to 2020. Methods: The data of 36,782 patients who underwent five markers of hepatitis B detection from Jan 2016 to Dec 2020 in 3 general hospital in Dazhou city were collected and analyzed statistically. Results: The HbsAg positive rate in Dazhou from 2016 to 2020 was 2.43%, and the annual change of HbsAg positive rate showed a decreasing trend (χ2= 57.274,P<0.001); The HbsAg positive rate of male (2.82%) was higher than that of female (2.04%)(χ2= 42.482,P<0.001); There was significant difference in the HbsAg positive rate among different age groups (χ2= 246.595,P<0.001). The lowest positive rate was found in 5-year-old group (0.76%), and the highest positive rate was found in 35-54 group (3.07%); Among the main modes of HBs Ag carrying, big three Yang(22.60%),small three Yang(41.95%) and 1,5positive(23.60%) accounted for 88.15%；1,5 positive rate in male (25.58%)was higher than that in female(20.90%)(χ2=18.645,P＜0.05);1,5 positive rate(30.77%)and small three Yang(62.33%) in 35～54-age people were highest; big three Yang(41.46%) in 15～24-age people was highest; 60.11% people were negative for all the five markers, among them, the highest was ≤5 age people(77.67%).Conclusion: In the past five years, the positive rate of HbsAg in male was higher than that of female in Dazhou, and it was mainly in young adults,which should be regarded as the key object of prevention and treatment, and at the same time, attention should be paid to children, mainly focusing on the prevention and treatment of the three Yang and three Yang and the total negative pattern of the population, so as to do a good job of three-level prevention.